NEWS & TOPICS
Biol. Pharm. Bull. Vol. 47 No. 2
2024/04/02
Cover
A Novel Strategy for the Discovery of Drug Targets: Integrating Clinical Evidence with Molecular Studies
pp. 345-349
A Novel Strategy for the Discovery of Drug Targets: Integrating Clinical Evidence with Molecular Studies
pp. 345-349
Graphical Abstracts
Review
A Novel Strategy for the Discovery of Drug Targets: Integrating Clinical Evidence with Molecular Studies
Shuji Kaneko
Drug Discovery Research for Traumatic Brain Injury Focused on Functional Molecules in Astrocytes
Shotaro Michinaga
Regular Article
Association between the Prognostic Nutritional Index and the Occurrence of Immune-Related Adverse Events
Tatsuya Furuno, Rintaro Sogawa, Takanori Hashimoto, Shunsuke Matsuo, Wakako Shirahama, Tomoko Kamura, Kazuhisa Hosoya, Yoko Senjyu, Yoshio Yamashita, Takuya Inoue, Moriyasu Yamauchi, Hiroo Katsuya, Mitsuru Noguchi, Naoko Sueoka-Aragane, and Chisato Shimanoe
Scraping Assay as a Novel Strategy to Evaluate Axonal Regeneration Using Human-Induced Pluripotent Stem Cell-Derived Neurons
Tomu Oonishi, Kaneyasu Nishimura, Kazuyuki Takata, Masahiro Fujimuro, and Yuichi Sekine
Efficacy of Glycicumarin and Isoliquiritigenin in Suppressing Colonic Peristalsis in Both an Animal Model and a Clinical Trial
Reo Kobayashi, Ken Inoue, Satoshi Sugino, Ryohei Hirose, Toshifumi Doi, Akihito Harusato, Osamu Dohi, Naohisa Yoshida, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yasuko Hirai, Katsura Mizushima, Yuji Naito, and Yoshito Itoh
Breed Differences in Serum Testosterone Levels of Male Pigs Are Highly Correlated with Differences in Testicular mRNA Levels of Enzymes and Proteins Involved in Testosterone Biosynthesis Process
Misaki Kojima, Jun-ichi Suto, and Masakuni Degawa
Note
Possible Involvement of Protein Binding Inhibition in Changes in Dexmedetomidine Concentration in Extracorporeal Circuits during Midazolam Use
Keishi Yamasaki, Masahiro Tokuno, Kenji Tsukigawa, Yuka Nagatsuka, Koji Nishi, Masaki Otagiri, and Yuhki Sato
Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing
Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, and Yuji Ikegaya
Regular Article
Icariin Regulates EMT and Stem Cell-Like Character in Breast Cancer through Modulating lncRNA NEAT1/TGFβ/SMAD2 Signaling Pathway
Bo Song, Fuxia Wei, Jiehao Peng, Xiuhong Wei, Mingran Liu, Zhongbiao Nie, Yanmiao Ma, and Tao Peng
Analysis of Adverse Events Associated with Trastuzumab Deruxtecan in Patients with Gastric and Breast Cancer: A Retrospective Study
Yuma Nonomiya, Izuma Nakayama, Kazuo Kobayashi, Yoshihiro Amakawa, Naoki Shibata, Azusa Soejima, Kazuyoshi Kawakami, Hisanori Shimizu, Daisuke Takahari, Saori Kawai, Fumikata Hara, Toshimi Takano, Kensei Yamaguchi, and Masakazu Yamaguchi
A Morpholine Derivative N-(4-Morpholinomethylene)ethanesulfonamide Induces Ferroptosis in Tumor Cells by Targeting NRF2
Bingchun Sun, Ligang Zhang, Binhua Wu, and Xiping Luo
Novel Screening System for Biliary Excretion of Drugs Using Human Cholangiocyte Organoid Monolayers with Directional Drug Transport
Kenta Mizoi, Ryo Okada, Arisa Mashimo, Norio Masuda, Manabu Itoh, Seiichi Ishida, Daiju Yamazaki, and Takuo Ogihara
Potent Efficacy of 3-Amino-4-hydroxy Benzoic Acid, a Small Molecule Having Anti-fibrotic Activity, in a Mouse Model of Non-alcoholic Steatohepatitis
Tomoaki Yamaguchi, Keita Shibata, Keiji Hasumi, and Koji Nobe
Comparison of the Effectiveness of Vedolizumab and Ustekinumab in Crohn's Disease Patients Who Failed Anti-tumor Necrosis Factor-α Treatment in Japan: An Observational Study Utilizing Claims Database
Minoru Shimazaki, Yutaka Matsuyama, and Daisuke Koide
Note
Substrate-Dependent Alteration in the C- and O-Prenylation Specificities of Cannabis Prenyltransferase
Ryosuke Tanaya, Takeshi Kodama, Juthamart Maneenet, Yoko Yasuno, Atsushi Nakayama, Tetsuro Shinada, Hironobu Takahashi, Takuya Ito, Hiroyuki Morita, Suresh Awale, and Futoshi Taura
Regular Article
Immune Checkpoint Inhibitor Is Associated with Improved Survival in Advanced Non-small Cell Lung Cancer Occurring in Patients with Autoimmune Disease
Yasutaka Ihara, Kenji Sawa, Takumi Imai, Yuta Nonomiya, Yuki Shimomura, Asahi Ishihara, and Ayumi Shintani
Note
Low Atmospheric Oxygen Attenuates Alpha Oscillations in the Primary Motor Cortex of Awake Rats
Masashi Kawamura, Airi Yoshimoto, Yuji Ikegaya, and Nobuyoshi Matsumoto
Regular Article
Peritoneal B Cells Play a Role in the Production of Anti-polyethylene Glycol (PEG) IgM against Intravenously Injected siRNA-PEGylated Liposome Complexes
Taro Shimizu, Amr S. Abu Lila, Yuka Kitayama, Ryo Abe, Haruka Takata, Hidenori Ando, Yu Ishima, and Tatsuhiro Ishida
Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner
Yumi Hirato, Kaoru Seiriki, Leo Kojima, Shohei Yamada, Hiroki Rokujo, Tomoya Takemoto, Takanobu Nakazawa, Atsushi Kasai, and Hitoshi Hashimoto
Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways
Zi-yi Xia, Ling Liu, Chiu-fai Kuok, Xue-li Wang, Dan Shi, Quan Ma, Xiao-yang Cheng, Guo-li Wang, Min-jing Li, Qiu-sheng Zheng, Xiao-na Liu, De-fang Li, and Bo-han Li
Renal Metabolomics Study and Critical Pathway Validation of Shenkang Injection in the Treatment of Chronic Renal Failure
Lin Zhou, Xiaohui Wang, Yi Zhang, Yan Xie, Rui Cui, Jinlan Xia, and Zhi Sun
Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein
Ayaka Ikemizu, Daisuke Hatta, Kohei Fujimoto, Mikako Honda, Kaori Watanabe, Kaname Ohyama, Naotaka Kuroda, Takashi Tanaka, Keiro Shirotani, and Nobuhisa Iwata
Self-controlled Case Series Study for Acute Kidney Injury after Starting Proton Pump Inhibitors or Potassium-Competitive Acid Blocker in Patients with Cancer Using a Large Claims Database
Kosuke Suzuki, Ayako Watanabe, Yoshihiro Kiryu, Eisuke Inoue, and Kenji Momo
Notes
Emedastine Inhibits Th1 and Th2 Cell Differentiation Mediated by Mast Cells
Katsuhiko Matsui, Akari Kuroki, and Aya Morishima
Regular Article
The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model
Remi Yoshii, Shigeki Adachi, Haruko Ryo, Eiko Hatanaka, Koujun Yasuda, Momoyo Kaji, Kumiko Enomoto, Jun Takanari, Katsuhide Yoshidome, Taisei Nomura, and Noriyuki Tomiyama
Metformin Attenuates Manganese-Induced Oxidative Stress in N27-A Dopaminergic Neuronal Cells
Jae-Sung Kim, Jeong-Yeon Seo, Kyeong-Rok Kang, HyangI Lim, Do Kyung Kim, and Hong Sung Chun
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