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Strengthening the Competitiveness of Japan's Pharmaceutical Industry: Analysis of Country Differences in the Origin of New Drugs and Japan's Highly Productive Firm
pp. 718-724

Review

Development of Therapeutic Agents with a Novel Mechanism of Action Targeting Pancreatic β-Cells for Diabetes

Yukiko K. Kaneko

Regular Articles

Anti-inflammatory Activity of Gegen Decoction and Its Modulatory Mechanism on the NF-κB and MAPK Signaling Pathways

Yinhe Gao, Yonggang Zhang, Qingran Zhang, Wenting Song, Hui Xu, Daquan Chen, and Feng Zhao

Analysis of Appendicitis Cases in the Japanese Adverse Drug Event Report (JADER) Database

Yoji Kyotani, Jing Zhao, Kiichi Nakahira, and Masanori Yoshizumi

Effects of Antibacterial Agents on Cancerous Cell Proliferation

Masahiko Imai, Tomohiro Izumisawa, Daisuke Saito, Shinya Hasegawa, Masahiro Yamasaki, and Noriko Takahashi

Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation

Yu Zhang, Chong Li, Zhifang Wang, Tingting Wang, Yahui Zhou, and Lili Zheng

Flavokavain C Suppresses Breast Cancer Cell Viability and Induces Cell Apoptosis by Triggering DNA Damage

Xiaoyu Lin, Sunhui Xing, Kejie Chen, Huamao Yang, and Xiaoqu Hu

Combination Therapy with Betamethasone and Josamycin Demonstrates Superior Therapeutic Efficacy in an NC/Nga Mouse Model of Atopic Dermatitis

Katsuhiko Matsui, Madoka Muranaka, Tomoka Yamaguchi, and Manami Maeda

Regional Disparity in First-in-Class Anticancer Drug Development in the US, EU, and Japan

Yoshitsugu Hino, Miu Okada, Christine Erikstrup Hallgreen, Marie Louise De Bruin, Randell E Doty, Naoki Matsumaru, and Katsura Tsukamoto

Effect of Ointment Base on the Skin Wound-Healing Deficits in Streptozotocin-Induced Diabetic Rat

Hiroko Otake, Yu Mano, Saori Deguchi, Fumihiko Ogata, Naohito Kawasaki, and Noriaki Nagai

Rapid Screening Detection of Genetically Modified Papaya by Loop-Mediated Isothermal Amplification

Reona Takabatake, Yukari Kagiya, Satoshi Futo, Yasutaka Minegishi, Keisuke Soga, Norihito Shibata, and Kazunari Kondo

Strengthening the Competitiveness of Japan's Pharmaceutical Industry: Analysis of Country Differences in the Origin of New Drugs and Japan's Highly Productive Firm

Ryo Okuyama

Notes

Possible Involvement of Dermal Fibroblasts in Modulating Nrf2 Signaling in Epidermal Keratinocytes

Yoshinobu Tsuruta, Yushi Katsuyama, Yuri Okano, Toshiyuki Ozawa, Satoshi Yoshimoto, Hideya Ando, Hitoshi Masaki, and Masamitsu Ichihashi

Convenient Application of a Compact-Type Magnetic Resonance Imager with Blood Pool Contrast Agent Gadolinium-Conjugated Dextran to Assess Vascular Abnormalities in Experimental Animals

Keizo Takeshita, Risa Sawada, Kotaro Ishizaka, Ryoya Maki, Yuta Sakamoto, Masashi Nishida, Yuhei Ohta, Jun Fang, and Shoko Okazaki

Calculation of Human Melatonin Partial Metabolic Clearance in Healthy Adult Volunteers for Investigation of a Novel in Vivo CYP1A2 Phenotyping Method: A Pilot Study

Seiya Ohki, Shingo Ogawa, Hiroki Takano, Hayato Shimazaki, Momoka Fukae, Tomomi Furihata, Hiromi Shibasaki, and Akitomo Yokokawa

Transcriptional Mechanism of the Mouse β4-Galactosyltransferase 6 Gene in Mouse Neuroblastoma Cell Line Neuro-2a

Masanobu Nihei, Saori Kawaguchi, Anri Mineyama, and Takeshi Sato

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