S22 Pathogenic Mechanism, Diagnosis and Therapy of Alzheimer's Disease: Current Understanding and Perspective S22-1 Intrabrain APP metabolism suppressed by X11-like/X11L S22-2 Modulation of beta- and gamma-secretases for the treatment of Alzheimer disease S22-3 Analysis of Aβ metabolic mechanism and identification of a novel therapeutic target for Alzheimer disease S22-4 Molucular mechanism of cerebral Abeta elimination across the brain barriers S22-5 Biomarkers of dementia: cerebrospinal fluid-specific glycoproteins