S-28 Mechanisms on the Endothelial Dysfunction and Drug Therapy S28-1 The role of NOS-derived superoxide in vascular disorders S28-2 Insulin signaling defect in endothelial cells causes skeletal muscle insulin resistance S28-3 Important role of endothelium-derived hyperpolarizing factor on diabetic microvascular complications S28-4 Nitrate tolerance and endothelial dysfunction S28-5 Endothelial and inducible NO synthase in septic shock: Potential therapeutic usefulness of statins S28-6 Role of bradykinin in the angiotensin II type 2 receptor-mediated vasodilatation