S57 Defensive' Ion Channels as Potential Therapeutic Targets S57-1 Physiological roles of STIM-dependent calcium influx on B cells S57-2 Roles of Ca2+-activated K+ channel in immune system S57-3 Role of P2X ion-channels on mechanisms of chronic pain S57-4 Pathophysiological roles of TRP channels in glial cells S57-5 Physiological role of the oxidative stress-sensitive TRPM2 Ca2+ channel in immunocytes