S-39 Frontier Pharmaceutics to Be Explored by Young Scientists: Drug Toxicicity and Challenges to It’s Avoidance S39-1 Percellome analysis of early liver gene expression alteration induced by hepatotoxicants S39-2 Drug response in the central nervos system and efflux system at the blood-brain barrier S39-3 Transporter-mediated drug-drug interactions S39-4 Adverse drug reactions and xenobiotic-sensing nuclear receptors S39-5 Mechanism for circadian clock-controlled rhythm of drug metabolism and  excretion S39-6 Approach for the development of low-toxic DDS based on the control of tissue distribution and intracellular trafficking