S-11 Development of Humanized Mouse and It’s Application to the Drug Discovery S11-1 Humanized model mice containing human gene(s) or gene cluster using chromosome engineering technology for medical application S11-2 Antibody therapeutics from mice with humanized immunoglobulin loci      S11-3 Prediction of drug metabolism in humans by using CYP3A-HAC mice S11-4 Development of chimeric mice with human hepatocytes and their characters S11-5 The utilization of chimeric mice with humanized liver in drug discovery and development.