S-22 New chalenges to cutting-edged non-parenteral drug delivery   S22-1. Drug metabolism and transport in mucus membrane   S22-2. Perspective of trans-mucosal delivery using tight junction modulators   S22-3. Blood-retinal barrier transport and drug delivery to the retina   S22-4. Transnasal drug delivery into the brain for new CNS active molecules: PK modeling of drug distribution after intranasal, intravenous and intracerebral administration of imatinib   S22-5. Pulmonary delivery of drug nanoparticles-containing microspheres   S22-6. Possibility of enhanced transdermal drug delivery and devices