S-21 Contribution to New 5 Yearly Clinical Trial Activation Plan by Pharmaceutical　Science and Pharmacist.   S21-1. New Five Yearly Clinical Trial Activation Plan and its status of implementation   S21-2. New system and a part of Pharmacist in the core Clinical Research Center and the Major Trial Institutions－from a clinical research coordinator’s（a pharmacist’s）point of view－   S21-3. A Principle Investigators View.   S21-4. Basic principles on Global Clinical Trials, from the viewpoint of reviewer   S21-5. Challenges for Implementation of Global Clinical Trials: Sponsor’s Perspectives