S-14 Is It Possible to Predict the Clinically Relevant Adverse Effects of Therapeutic Drugs by in Vitro Pharmacokinetic Studies?   S14-1. The Involvement of Transporters in Clinically Relevant Drug-Drug Interactions   S14-2. Changes in the Functional Expression of Drug Transporters under Hepatic Dysfunctions   S14-3. The Impact of Genetic Polymorphisms of Transporters on the Clinical Pharmacokinetics and Its Prediction from the Results of in Vitro Experiments   S14-4. Clinical Application of in Vitro Pharmacokinetic Studies on Individualized Pharmacotherapy   S14-5. Recent Basic Researches on Drug Interactions and Their Application for the Clinical Pharmacotherapy