S56 Recent Development in Blood Coagulation Factors, Coagulation-related Drugs and Blood Products S56-1 Blood coagulation factors and anticoagulant drugs: Present state and perspectives S56-2 Intracellular accumulation of mutant serpin and cellular response S56-3 Clinical practice of heparin-induced thrombocytopenia (HIT) S56-4 Pharmacogenomic mechanisms of interinvididual variability in anticoagulation responses to vitamin K antagonists and advances in individualized medicine S56-5 Development of a new treatment for DIC, thrombomodulin alfa (genetical recombination) -focus on clinical development S56-6 New drug evaluation and blood products