S48 New Development of Histamine Research in Allergic Inflammation S48-1 Pathlogical significance of histamine H1 receptor gene expression mechanism S48-2 Roles of histamine in exacerbated allergic dermatitis S48-3 The role of histamine H4 receptor in allergic rhinitis S48-4 Roles of histamine in pathogenesis of asthma and re-evaluation of clinical efficacy of anti-histaminic drugs