S46 Local Dynamics of Prostaglandins as New Drug Targets: From Their Biosynthesis to Metabolism S46-1 Microsomal prostaglandin E synthase-1: a novel therapeutic target? S46-2 Physiological roles of interactions between prostaglandin and chemokine signaling S46-3 The roles of a novel PG transporter in the local clearance and metabolism of PGE2 in renal cortex S46-4 PGE2 circulation in renal cortex and blood pressure regulation S46-5 Development of NS-304, a selective and long-acting prostacyclin receptor agonist, as a novel drug for pulmonary hypertension