CS-2 PSJ-AAPS Joint Symposium: New Trends of Medicinal Chemistry CS2-1 Retrometabolic Drug Design: Principles and Recent Advances CS2-2 Chemical Approaches to a Novel Natural Product Pladienolide CS2-3 Role of Molecular Size in Determining Pharmaceutically Relevant Properties: Linear and Bilinear Models CS2-4 Defying Difficult Diseases: Design and Synthesis of Protease Inhibitors, Prodrug Forms and Click Peptides